I’m on day 3 of the 5-day mimicking diet. 800 calories per day, except the first day I went without food entirely.
Focus on the mimicking diet is minimizing protein so to maximize the amount of autophagy. Less than 20 grams of protein per day, except that first day was 0. From Longo’s book The Longevity Diet.
Really want the body to have to scavenge for protein wherever it can find it — all those wayward (and cancerous?) cells.
Longo says a healthy person should do this 3 times per year. Someone with diabetes much more often.
I knew I could do this because I did one similar 800 calorie day before and it wasn’t difficult. I thought I could boost the benefit by not eating that first day, which I knew I could do because I’ve done 48-hour fasts before.
Those more strenuous fasts one has to work one’s way up to them imo. Not sure I want to do a 5-day water fast because I do notice with a 48-hour fast that my energy level goes down significantly. One must feel very depleted after 5 days with no nutrition — really don’t want to experience that level of fatigue.
Looks pretty clear that a 3-day water fast does a lot in terms of fighting cancer. Cancer cells grow using glucose, not ketones, but if you are fasting, there is no added glucose for cancer cells to use. Also, the lack of additional protein undermines tumor growth.
A long water fast stimulates autophagy, which may mean the actual destruction of cancer cells.
A long water fast also simulates the immune system, which may be a key player in fighting off cancer. There have been many authorities assert that long fasts are beneficial for those doing chemo, largely because of this effect of restoring the immune system, which otherwise gets whacked on chemo.
The Keto diet with low carbohydrates and moderate protein might be the best choice for a cancer patient. Again, low carbohydrates minimizes the amount of glucose available. so cancer cells “starve”.
There’s quite a bit of evidence that mushrooms have the effect of minimizing blood vessel growth. This can help with cancerous tumors as these tumors need blood vessels in order to continue growing.
The consensus among scientists seems to be that you have to go from 48 to 72 hours fasting to induce serious autophagy, and from there it just escalates the longer you go.
But here’s the issue. They know that eating protein is counterproductive for autophagy, which is logical since cell regeneration requires ammo acids, so if you provide ammo acids in your food, then the body doesn’t have to scalp for them in senescent cells.
But then one should consider the opposite. What if one severely restricts the grams of protein one eats in one’s diet? Would that severe restriction induce the start of serious autophagy sooner than the 48 hours commonly believed to be the earliest threshold?
I’ve read that the body needs approximately 300 grams of protein for its daily recycling of cells throughout the body. Assuming that one eats 100 grams of protein in one’s diet, that would mean that the body takes 200 grams from it ammo acid pool — makes up the difference that way.
But what if one restricts the daily protein from food to only 15 grams — 85 grams less that what one usually eats? Would that restriction induce a faster autophagy, as now the body needs to find 285 grams, not just 200 grams, within itself for the daily recycling? Would not the additional 85 grams required induce sooner autophagy? Seems logical.
And what if one were to continue to restrict to only 15 grams of protein in subsequent days. Would that continued severe restriction escalate the autophagy faster?
These all seem to be logical assumptions, but I’m not sure anyone has explored any of these ideas on humans in actual experiments to prove these possibilities with autophagy one way or the other.