The consensus among scientists seems to be that you have to go from 48 to 72 hours fasting to induce serious autophagy, and from there it just escalates the longer you go.
But here’s the issue. They know that eating protein is counterproductive for autophagy, which is logical since cell regeneration requires ammo acids, so if you provide ammo acids in your food, then the body doesn’t have to scalp for them in senescent cells.
But then one should consider the opposite. What if one severely restricts the grams of protein one eats in one’s diet? Would that severe restriction induce the start of serious autophagy sooner than the 48 hours commonly believed to be the earliest threshold?
I’ve read that the body needs approximately 300 grams of protein for its daily recycling of cells throughout the body. Assuming that one eats 100 grams of protein in one’s diet, that would mean that the body takes 200 grams from it ammo acid pool — makes up the difference that way.
But what if one restricts the daily protein from food to only 15 grams — 85 grams less that what one usually eats? Would that restriction induce a faster autophagy, as now the body needs to find 285 grams, not just 200 grams, within itself for the daily recycling? Would not the additional 85 grams required induce sooner autophagy? Seems logical.
And what if one were to continue to restrict to only 15 grams of protein in subsequent days. Would that continued severe restriction escalate the autophagy faster?
These all seem to be logical assumptions, but I’m not sure anyone has explored any of these ideas on humans in actual experiments to prove these possibilities with autophagy one way or the other.